Decoding the Biology of Pain for Precision Therapies
Overview
Pain is more than a symptom; it is a complex, debilitating global health challenge with profound personal and societal costs. At the PROPA Lab, we are dedicated to dissecting pain at its most fundamental level. We move beyond traditional approaches to unravel the intricate molecular and genetic dialogues that initiate and sustain pain, aiming to rewrite the future of pain management.
Our Research Focus
Our research is built on a dual foundation: discovery and translation. We begin by using cutting-edge sequencing technologies and sophisticated bioinformatics to map the complex landscape of pain. This allows us to identify key player genes, regulatory non-coding RNAs, and critical signaling pathways that are dysregulated in various pain states. But we don’t stop at discovery. We translate these insights into action by collaborating with our in-house nanozyme team to engineer innovative, targeted therapeutics.
Key Research Terms
- The Chronic Pain Enigma: Why does acute pain sometimes transition into a persistent, chronic condition? We are investigating the molecular “switch”—the drivers and signaling cascades—responsible for this transition. By understanding the mechanisms behind pain chronification, we aim to develop interventions that can halt or reverse this process.
- Nanozyme-Based Neuromodulation: We are pioneering the use of nanozymes—nanoparticles with enzyme-like activity—as a novel class of therapeutics for neuropathic pain. Our strategies are multi-faceted, designing nanozymes that can simultaneously tackle oxidative stress, promote mitochondrial repair, and modulate neuroimmune interactions. This multi-target approach represents a new frontier in targeted, effective, and non-addictive pain relief.
