Engineering Biocatalysts for a Sustainable Future
In the pursuit of a greener planet, the PROPA Lab utilizing the power of nature’s most efficient catalysts: enzymes. Our Enzyme Engineering division is dedicated to redesigning and optimizing enzymes for demanding industrial applications, replacing harsh chemical processes with efficient, eco-friendly biocatalytic solutions.
Our Engineering Philosophy
We employ a powerful combination of computational and rational design strategies to create superior enzymes. Using computational mutagenesis, we can predict and model the effects of thousands of potential mutations in silico. This is combined with rational design, where we apply deep knowledge of protein structure-function relationships to make precise, intelligent alterations. This integrated approach allows us to enhance key enzyme properties such as activity under industrial conditions, thermal stability, and substrate specificity.
Current Projects & Impact
Optimizing Biofuel Pathways: We are engineering key enzymes in the biodiesel production chain, specifically glycerol dehydratase and aldehyde dehydrogenase, to create more efficient and cost-effective pathways for biofuel production. Our work aims to increase yield and stability, making biofuels a more viable alternative to fossil fuels.
Advancing Green Chemistry: By creating robust and highly specific biocatalysts, we are enabling cleaner manufacturing processes across industries—from pharmaceuticals to agrochemicals—minimizing waste and reducing environmental footprint.
